Drug interactions may be important risk factors for methotrexate neurotoxicity, particularly in pediatric leukemia patients
نویسندگان
چکیده
منابع مشابه
Methotrexate-induced neurotoxicity and leukoencephalopathy in childhood acute lymphoblastic leukemia.
PURPOSE Methotrexate (MTX) can cause significant clinical neurotoxicity and asymptomatic leukoencephalopathy. We sought to identify clinical, pharmacokinetic, and genetic risk factors for these MTX-related toxicities during childhood acute lymphoblastic leukemia (ALL) therapy and provide data on safety of intrathecal and high-dose MTX rechallenge in patients with neurotoxicity. PATIENTS AND M...
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ژورنال
عنوان ژورنال: Cancer Chemotherapy and Pharmacology
سال: 2016
ISSN: 0344-5704,1432-0843
DOI: 10.1007/s00280-016-3153-0